In addition to pre-pregnancy health checks to search for sexually transmitted diseases, diseases affecting pregnancy, diseases that may cause children to be born with abnormalities, and diseases that are inherited by children from parents, such as thalassemia,
there may also be an asymptomatic “latent genetic disease” that “can be passed on from parents to children”.
With today’s gene testing technology, we can detect latent genes responsible for both severe or more common diseases beforehand. Therefore, premarital examinations and family planning before having children are important in order to prevent your beloved child from contracting abnormalities in the future.
The Premarital & Preconception Genetic Screening package can detect 12 inherited diseases with severe or common symptoms. After determining whether the father or mother is a carrier of a latent gene, a medical professional will help your family planning by using the latest medical technologies, such as in vitro fertilization, pre-implantation embryo genetic selection, or prenatal genetic testing. This reduces the chances of your child developing a disease and reduces the transmission of inherited diseases to the next generation.
|Health check-up before having a baby and check for genetic abnormalities at the DNA level,|
in order to prevent and reduce the risks of inherited disease that could be passed on from parents to children.
|Physical Examination by an Obstetrician|
|Physician Consultation for Genetic|
|Hepatitis B surface Antigen|
|Hepatitis C Antibody|
|Complete Blood Count Test|
|Rh Blood Group|
|Thyroid Stimulating Hormone (TSH)|
|Varicella Zoster IgG|
|Cervical Cancer Screening (Co-testing)|
|Genetic Carrier Screening|
|Hospital and Nursing Service fees|
|Health check-up report in E-Report format|
|Expires on 31 December, 2022|
|Women’s Health Centre, 4th Floor, BNH Hospital|
|12 Inherited diseases with severe or common symptoms|
|Type of disease|
|Incidence of disease|
|Symptoms of disease|
|Alpha – Thalassemia|
|1 in 5 are carriers|
|A disease caused by abnormalities in the HBA 1 and HBA 2 genes that affect the production of the alpha-globin protein in red blood cells, which could lead to stillbirth or cause anemia in the child. This disorder is more common in Asian people, therefore, parents should be screened for this disease before having a baby.|
|Beta – Thalassemia|
|1 in 10 are carriers|
|A disease caused by a mutation in the HBB gene that affects the production of the beta-globin protein in red blood cells. It causes anemia, whose severity depends on the type of gene mutation. Parents should therefore be screened for being carriers before having a baby.|
|Autosomal Recessive Deafness|
|4 in 50 are carriers|
|Deafness, where a recessive gene is inherited from a carrier parent who does not show symptoms or have a prior family history of deafness.|
|Spinal Muscular Atrophy|
|1 in 50 are carriers|
|A disease caused by spinal cord neurons that control the movement of muscles. Stops cells from dividing, causing to stop growing, atrophy, smaller muscles, and slower muscle development. If the father or mother are carriers, the child has a 1 in 4 chance of getting this disease.|
|1 in 60 are carriers|
|A disease caused by an abnormality in the mother’s or father’s genes, causing an abnormality in phenylalanine, the enzyme that digests amino acids. Newborns appear to be like normal children, but if left undiagnosed or untreated, they will have severe developmental delays, small heads, and seizures.|
|1 in 100 are carriers|
|A disease caused by a mutation in the ATP7B gene that is passed on from the parents. The ATP7B gene is responsible for bringing copper to the liver; therefore, children will have symptoms of liver disease such as jaundice, hepatitis, and liver failure from the age of 3 years old.|
|Glycogen Storage Disease type II|
|1 in 100 are carriers|
|A disease caused by Acid-alpha-Glycogen enzyme deficiency that initiates accumulation of glycogen in the muscles, especially the heart muscle. Currently, the treatment requires lifelong enzyme replacement.|
|Fragile X Syndrome 1|
|1 in 1,000 boys|
|A disorder often found in males, where the carriers are females. People with this disorder experience delayed cognitive development,|
and may also have symptoms of autism.
|Duchenne Muscular Dystrophy|
|1 in 3,600 boys|
|Found in males, causing the development of movement that uses the large muscles to be delayed, making it difficult for children to move. The symptoms will keep getting worse, such that sufferers may have to use a wheelchair before adolescence. Males of carrier mothers have a 1 in 2 chance of developing the disease.|
|3 in 30,000 boys|
|Hemophilia B is commonly found in males. In severe cases, it may lead to bleeding in joints, gastrointestinal tract, urinary tract, and the brain.|
|1 in 60,000|
|A condition caused by a deficiency of the enzyme that breaks down galactose into glucose, causing high blood sugar.|
Symptoms such as jaundice, hepatitis, lethargy, and immaturity can occur in the early days of life after ingesting lactose-containing breast milk.
|1 in 100,000|
|A chronic disease caused by the transmission of genes from parents. This causes the production of sputum in lungs and pancreatic mucus,|
resulting in rapid infection and life-threatening lung damage.
|*References: Statistics on Thalassemia for the Thai population from the Ministry of Public Health, and other diseases from medical journals.|
What is the importance of “pre-marriage and pre-pregnancy” health screening?
- Prevent diseases that can be transmitted among sexual partners, such as AIDS, syphilis, and hepatitis B.
- Protect against hepatitis B virus, which the baby has a 90% chance of contracting from the mother during delivery.
- Prevent contracting rubella infection, passed on from mother to child, which can cause abnormalities.
- Prevent thalassemia, or anemia, an inherited diseases from parents to child, which in turn causes other diseases and complications such as small babies, and abnormal liver and heart function (45% of Thais are thalassemia carriers).
- It can be dangerous if a woman has diabetes, high blood pressure, anemia, thyroid disease, or heart disease during pregnancy. To be safe, she should be closely supervised by a specialist in combination with an obstetrician and a gynecologist.
- Prevent immature and slow growth of the baby, miscarriage, or premature birth
- by ensuring the mother’s health through internal examination, such as testing the integrity of the uterus and ovaries (Ultrasound Transvaginal), including HPV testing and cell changes, to determine the presence cervical cancer (ThinPrep and HPV DNA
- Increase your chances of getting pregnant with advice on ovulation or fertility problems.)
With over 124 years of expertise and experience, especially in women’s health, midwifery, and mothers and children, BNH is ready to take care of the health of everyone in the family to be strong and healthy every day, as you have entrusted us with caring for your health throughout your entire your life.
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